Ixabepilone;
Breast cancer;
Microtubule-stabilising;
Sensory-motor neuropathy;
Adverse drug reaction;
PHASE-II;
EPOTHILONES;
D O I:
10.1007/s12094-009-0440-9
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Ixabepilone is a novel microtubule-stabilising agent used as monotherapy or in combination with capecitabine to treat taxane- and anthracycline-refractory breast cancer. We report the case of a patient who experienced an unusual motor neuropathy after the first cycle. This is a very uncommon secondary effect, but it must be taken into account as a possible complication of treatment with ixabepilone.
机构:
Univ N Carolina, Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27514 USAUniv N Carolina, Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27514 USA
Bhushan, Shriya
;
Walko, Christine M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27514 USAUniv N Carolina, Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27514 USA
机构:
Northwestern Univ, Feinberg Sch Med, Div Hematol Oncol, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Div Hematol Oncol, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA
机构:
Montefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Albert Einstein Coll Med & Canc Ctr, Dept Oncol, Bronx, NY USAMontefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Goel, S.
;
Goldberg, G. L.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med & Canc Ctr, Dept Oncol, Bronx, NY USA
Montefiore Med Ctr, Div Gynecol Oncol, Bronx, NY 10461 USAMontefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Goldberg, G. L.
;
Kuo, D. Y. -S.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med & Canc Ctr, Dept Oncol, Bronx, NY USA
Montefiore Med Ctr, Div Gynecol Oncol, Bronx, NY 10461 USAMontefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Kuo, D. Y. -S.
;
Muggia, F.
论文数: 0引用数: 0
h-index: 0
机构:
NYU Ctr Inst, Dept Oncol, New York, NY USAMontefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Muggia, F.
;
Arezzo, J.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10467 USAMontefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Arezzo, J.
;
Mani, S.
论文数: 0引用数: 0
h-index: 0
机构:
Montefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Albert Einstein Coll Med & Canc Ctr, Dept Oncol, Bronx, NY USAMontefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
O'Connor, Owen A.
;
Portlock, Carol
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Portlock, Carol
;
Moskowitz, Craig
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Moskowitz, Craig
;
Straus, David
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Straus, David
;
Hamlin, Paul
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Hamlin, Paul
;
Stubblefield, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Rehabil Med, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Stubblefield, Michael
;
Dumetrescu, Otila
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Dumetrescu, Otila
;
Colevas, A. Dimitrios
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Canc Therapy & Evaluat Program, Bethesda, MD 20892 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Colevas, A. Dimitrios
;
Grant, Barbara
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vermont, Vermont Reg Canc Ctr, Burlington, VT USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Grant, Barbara
;
Zelenetz, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
机构:
Univ N Carolina, Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27514 USAUniv N Carolina, Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27514 USA
Bhushan, Shriya
;
Walko, Christine M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27514 USAUniv N Carolina, Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27514 USA
机构:
Northwestern Univ, Feinberg Sch Med, Div Hematol Oncol, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Div Hematol Oncol, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA
机构:
Montefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Albert Einstein Coll Med & Canc Ctr, Dept Oncol, Bronx, NY USAMontefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Goel, S.
;
Goldberg, G. L.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med & Canc Ctr, Dept Oncol, Bronx, NY USA
Montefiore Med Ctr, Div Gynecol Oncol, Bronx, NY 10461 USAMontefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Goldberg, G. L.
;
Kuo, D. Y. -S.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med & Canc Ctr, Dept Oncol, Bronx, NY USA
Montefiore Med Ctr, Div Gynecol Oncol, Bronx, NY 10461 USAMontefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Kuo, D. Y. -S.
;
Muggia, F.
论文数: 0引用数: 0
h-index: 0
机构:
NYU Ctr Inst, Dept Oncol, New York, NY USAMontefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Muggia, F.
;
Arezzo, J.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10467 USAMontefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Arezzo, J.
;
Mani, S.
论文数: 0引用数: 0
h-index: 0
机构:
Montefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
Albert Einstein Coll Med & Canc Ctr, Dept Oncol, Bronx, NY USAMontefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
O'Connor, Owen A.
;
Portlock, Carol
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Portlock, Carol
;
Moskowitz, Craig
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Moskowitz, Craig
;
Straus, David
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Straus, David
;
Hamlin, Paul
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Hamlin, Paul
;
Stubblefield, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Rehabil Med, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Stubblefield, Michael
;
Dumetrescu, Otila
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Dumetrescu, Otila
;
Colevas, A. Dimitrios
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Canc Therapy & Evaluat Program, Bethesda, MD 20892 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Colevas, A. Dimitrios
;
Grant, Barbara
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vermont, Vermont Reg Canc Ctr, Burlington, VT USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA
Grant, Barbara
;
Zelenetz, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Div Hematol Oncol, Lymphoma Serv, New York, NY 10021 USA