Intense Diffuse Uptake of 68Ga-FAPI-04 in the Breasts Found by PET/CT in a Patient With Advanced Nasopharyngeal Carcinoma

被引:16
作者
Wang, Li-juan [1 ]
Zhang, Yin [1 ]
Wu, Hu-bing [1 ]
机构
[1] Southern Med Univ, Nanfang Hosp, PET Ctr, 1838 Guangzhou Ave North, Guangzhou 510515, Guangdong, Peoples R China
关键词
Ga-68-FAPI-04; breast; PET/CT; physiological uptake; STROMAL FIBROBLASTS; F-18-FDG PET/CT; CANCER;
D O I
10.1097/RLU.0000000000003487
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The physiological uptake of Ga-68-FAPI-04 due to the change of the internal environment is little known. We report the case of a 45-year-old woman who was highly suspected to have advanced nasopharyngeal carcinoma. F-18-FDG and Ga-68-FAPI-04 PET/CT was performed for evaluating the disease. Both PET and CT with different tracers detected the primary nasopharyngeal carcinoma and metastases in right neck lymph nodes, liver, and bones. To our surprise, intense diffuse uptake of Ga-68-FAPI-04 was found in both breasts, which might be due to the hormone stimulation because the patient received Ga-68-FAPi-04 PET/CT just at the period of ovulation.
引用
收藏
页码:E293 / E295
页数:3
相关论文
共 13 条
[1]   Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer [J].
Costa, Ana ;
Kieffer, Yann ;
Scholer-Dahirel, Alix ;
Pelon, Floriane ;
Bourachot, Brigitte ;
Cardon, Melissa ;
Sirven, Philemon ;
Magagna, Ilaria ;
Fuhrmann, Laetitia ;
Bernard, Charles ;
Bonneau, Claire ;
Kondratova, Maria ;
Kuperstein, Inna ;
Zinovyev, Andrei ;
Givel, Anne-Marie ;
Parrini, Maria-Carla ;
Soumelis, Vassili ;
Vincent-Salomon, Anne ;
Mechta-Grigoriou, Fatima .
CANCER CELL, 2018, 33 (03) :463-+
[2]   Stromal fibroblasts from the interface zone of human breast carcinomas induce an epithelial-mesenchymal transition-like state in breast cancer cells in vitro [J].
Gao, Ming-Qing ;
Kim, Baek Gil ;
Kang, Suki ;
Choi, Yoon Pyo ;
Park, Hangran ;
Kang, Kyu Sub ;
Cho, Nam Hoon .
JOURNAL OF CELL SCIENCE, 2010, 123 (20) :3507-3514
[3]   CELL-SURFACE GLYCOPROTEIN OF REACTIVE STROMAL FIBROBLASTS AS A POTENTIAL ANTIBODY TARGET IN HUMAN EPITHELIAL CANCERS [J].
GARINCHESA, P ;
OLD, LJ ;
RETTIG, WJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (18) :7235-7239
[4]   68Ga-FAPI and 18F-FDG PET/CT Images in a Patient With Extrapulmonary Tuberculosis Mimicking Malignant Tumor [J].
Gu, Bingxin ;
Luo, Zhiguo ;
He, Xinhong ;
Wang, Jian ;
Song, Shaoli .
CLINICAL NUCLEAR MEDICINE, 2020, 45 (11) :865-867
[5]   Hormonal Effects on Breast Density, Fibroglandular Tissue, and Back-ground Parenchymal Enhancement [J].
Heller, Samantha L. ;
Lin, Leng Leng Young ;
Melsaether, Any N. ;
Moy, Linda ;
Gao, Yiming .
RADIOGRAPHICS, 2018, 38 (04) :983-996
[6]   68Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer [J].
Kratochwil, Clemens ;
Flechsig, Paul ;
Lindner, Thomas ;
Abderrahim, Labidi ;
Altmann, Annette ;
Mier, Walter ;
Adeberg, Sebastian ;
Rathke, Hendrik ;
Roehrich, Manuel ;
Winter, Hauke ;
Plinkert, Peter K. ;
Marme, Frederik ;
Lang, Matthias ;
Kauczor, Hans-Ulrich ;
Jaeger, Dirk ;
Debus, Juergen ;
Haberkorn, Uwe ;
Giesel, Frederik L. .
JOURNAL OF NUCLEAR MEDICINE, 2019, 60 (06) :801-805
[7]   Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein [J].
Lindner, Thomas ;
Loktev, Anastasia ;
Altmann, Annette ;
Giesel, Frederik ;
Kratochwil, Clemens ;
Debus, Juergen ;
Jaeger, Dirk ;
Mier, Walter ;
Haberkorn, Uwe .
JOURNAL OF NUCLEAR MEDICINE, 2018, 59 (09) :1415-1422
[8]   A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts [J].
Loktev, Anastasia ;
Lindner, Thomas ;
Mier, Walter ;
Debus, Juergen ;
Altmann, Annette ;
Jaeger, Dirk ;
Giesel, Frederik ;
Kratochwil, Clemens ;
Barthe, Philippe ;
Roumestand, Christian ;
Haberkorn, Uwe .
JOURNAL OF NUCLEAR MEDICINE, 2018, 59 (09) :1423-1429
[9]   Intense FAPI Uptake in Inflammation May Mask the Tumor Activity of Pancreatic Cancer in 68Ga-FAPI PET/CT [J].
Luo, Yaping ;
Pan, Qingqing ;
Zhang, Wen ;
Li, Fang .
CLINICAL NUCLEAR MEDICINE, 2020, 45 (04) :310-311
[10]   Recurrent Immunoglobulin G4-Related Disease Shown on 18F-FDG and 68Ga-FAPI PET/CT [J].
Pan, Qingqing ;
Luo, Yaping ;
Zhang, Wen .
CLINICAL NUCLEAR MEDICINE, 2020, 45 (04) :312-313