Radiation Dose Enhancement in Megavoltage Radiation Therapy using Au, Gd, Pt, Ag, and Bi Nanoparticles of Various Concentration Level

被引：4

作者：

Abolaban, Fouad ^{[1
]}

Nisbet, Andrew ^{[2
]}

机构：

[1] King Abdulaziz Univ, Coll Engn, Nucl Engn Dept, Jeddah, Saudi Arabia

[2] UCL, Dept Med Phys & Biomed Engn, Malet Pl Engn Bldg, London WC1E 6BT, England

来源：

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | 2022年 / 12卷 / 02期

关键词：

dose enhancement; GATE Monte Carlo; nanoparticles; dosimetry; GOLD NANOPARTICLES; MONTE-CARLO; RADIOTHERAPY; RADIOSENSITIZATION;

D O I：

10.33263/BRIAC122.24042414

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A digital phantom as created from a CT scan of a patient's head and employed together with GATE 8.2 Monte Carlo modeling of a linear accelerator of nominal 6 MV energy to simulate an irradiation geometry for a typical tumor volume centrally within the brain region. Although simplistic in arrangement this setup as considered appropriate to demonstrate the dose enhancements that may be expected for megavoltage external beam radiation therapy for nanoparticles (NP) of different elemental composition and concentration. Ag, Gd, Pt, Au and Bi ere modeled in concentrations varying from 15 mg NP / gram tissue to 70 mg NP / gram tissue. The maximum Average Dose Enhancement Factor (ADEF) to the Gross Tumour Volume (GTV) observed as 3 % for 70 mg NP / gram tissue of Bi.

引用

页码：2404 / 2414

页数：11

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