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- [1] Halofluorination of Alkenes Using Trihaloisocyanuric Acids and HF•PyridineSYNTHESIS-STUTTGART, 2010, (14): : 2379 - 2382Crespo, Livia T. C.Ribeiro, Rodrigo da S.de Mattos, Marcio C. S.Esteves, Pierre M.
Practical fluorothiolation and difluorothiolation of alkenes using pyridine-HF and N-thiosuccinimides
被引：15
|作者：
Liu, Shiwen
[1
,2
]
Zeng, Xiaojun
[2
]
Xu, Bo
[2
]
机构：
[1] Yancheng Inst Technol, Coll Text & Clothing, Yancheng 224051, Peoples R China
[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Minist Educ, Key Lab Sci & Technol Ecotext, Shanghai 201620, Peoples R China
基金：
美国国家科学基金会;
关键词：
COPPER-MEDIATED DIFLUOROMETHYLATION;
NUCLEOPHILIC DIFLUOROMETHYLATION;
HYDROHALOGENATION REACTION;
METHANESULFENYL FLUORIDE;
ALPHA-FLUORINATION;
FORMAL ADDITION;
METAL-FREE;
TRIFLUOROMETHYLATION;
ARYL;
HALIDES;
D O I：
10.1039/c9qo01228a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ;
081704 ;
摘要：
We have developed highly efficient fluorothiolation and difluorothiolation of alkenes under simple and mild conditions. Our fluorothiolation reagents are the commercially available Olah's reagent (Py-HF) and readily available N-thiosuccinimides. This transition metal-free system offers good chemical yields for a wide range of alkene substrates with excellent regioselectivity and good functional group tolerance.
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页码：119 / 125
页数：7
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