Effects of Physical Damage in the Intermediate Phase on the Progression of Amyloid β Fibrillization

被引：9

作者：

Tashiro, Ryu ^{[1
]}

Taguchi, Hiroaki ^{[1
]}

Hidaka, Kumi ^{[2
]}

Endo, Masayuki ^{[2
]}

Sugiyama, Hiroshi ^{[2
,3
]}

机构：

[1] Suzuka Univ Med Sci, Fac Pharmaceut Sci, 3500-3 Minamitamagaki Cyo, Suzuka, Mie 5138670, Japan

[2] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan

[3] Kyoto Univ, Inst Integrated Cell Mat Sci WPI iCeMS, Sakyo Ku, Kyoto 6068501, Japan

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2019年 / 14卷 / 23期

关键词：

Alzheimer's disease; Amyloid; Fibrillization; High-speed AFM; Pathogenic Peptides; ALPHA-SYNUCLEIN; DYNAMICS; PEPTIDE;

D O I：

10.1002/asia.201901193

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Understanding the mechanism responsible for the progression of amyloid deposition is important for developing methods to suppress this process in the treatment of Alzheimer's disease. The effects of physical damage during the transition phase of amyloid beta fibril formation are unclear. In this study, we used high-speed atomic force microscopy to investigate the effects of damage to the intermediates of amyloid beta in real time. Physical damage to intermediates did not suppress, but instead promoted fibrillization. This progression was accompanied by morphological changes from globular oligomers to protofibrils. These results suggest that the properties of the intermediates, such as structural fragility and stability, are highly related to the rate of fibrillization.

引用

页码：4140 / 4145

页数：6

共 27 条

[21] Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation [J].