Sarcoma Metabolomics: Current Horizons and Future Perspectives

被引：9

作者：

Esperanca-Martins, Miguel ^{[1
,2
,3
]}

Fernandes, Isabel ^{[1
,3
,4
]}

Soares do Brito, Joaquim ^{[4
,5
]}

Macedo, Daniela ^{[6
]}

Vasques, Hugo ^{[4
,7
]}

Serafim, Teresa ^{[2
]}

Costa, Luis ^{[1
,3
,4
]}

Dias, Sergio ^{[2
,4
]}

机构：

[1] Ctr Hosp Univ Lisboa Norte, Hosp Santa Maria, Med Oncol Dept, P-1649028 Lisbon, Portugal

[2] Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, Vasc Biol & Canc Microenvironm Lab, P-1649028 Lisbon, Portugal

[3] Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, Translat Oncobiol Lab, P-1649028 Lisbon, Portugal

[4] Univ Lisbon, Fac Med, P-1649028 Lisbon, Portugal

[5] Ctr Hosp Univ Lisboa Norte, Hosp Santa Maria, Orthoped & Traumatol Dept, P-1649028 Lisbon, Portugal

[6] Hosp Lusiadas Lisboa, Med Oncol Dept, P-1500458 Lisbon, Portugal

[7] Inst Portugues Oncol Francisco Gentil, Gen Surg Dept, P-1099023 Lisbon, Portugal

来源：

CELLS | 2021年 / 10卷 / 06期

关键词：

sarcoma; soft tissue sarcoma; bone sarcoma; gastrointestinal stromal tumor; metabolomics; metabolism; SOFT-TISSUE SARCOMA; IN-VITRO; CELL-LINES; CANCER; OSTEOSARCOMA; TUMORS; METABOLISM; INHIBITORS; HALLMARKS; PATHWAY;

D O I：

10.3390/cells10061432

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction-oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism reprogramming strategies employed by cancer cells to proliferate. Knowledge regarding soft tissue and bone sarcomas metabolome is relatively sparse. Further characterization of sarcoma metabolic landscape may pave the way for diagnostic refinement and new therapeutic target identification, with benefit to sarcoma patients. This review covers the state-of-the-art knowledge on cancer metabolomics and explores in detail the most recent evidence on soft tissue and bone sarcoma metabolomics.

引用

页数：23

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