Inhibitory effect of hederagenin on Streptococcus pneumoniae pneumolysin in vitro

被引：6
|
作者：
Ding, Rui [1 ]
Zhang, Yan [2 ]
Xu, Xiangzhu [1 ]
Hou, Yunfeng [3 ]
Nie, Jing [3 ]
Deng, Xuming [1 ]
Qiu, Jiazhang [1 ]
Lv, Qianghua [1 ]
机构：
[1] Jilin Univ, Coll Vet Med, Inst Zoonosis, Key Lab Zoonosis Res,Minist Educ, Changchun 130062, Peoples R China
[2] Jilin Univ, Hosp Stomatol, Changchun 130021, Peoples R China
[3] Shandong Jinzhuji Pharmaceut Co Ltd, Jinan 271100, Shandong, Peoples R China
来源：
MICROBES AND INFECTION | 2022年 / 24卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Streptococcus pneumoniae; Pneumolysin; Hederagenin; Anti-virulence; VIRULENCE;
D O I：
10.1016/j.micinf.2021.104888
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Streptococcus pneumoniae is an important pathogen that causes otitis media, pneumonia, meningitis and bacteremia. As an important virulence factors of S. pneumoniae, pneumolysin (PLY) can penetrate cell membranes and lead to cell lysis and inflammation, which is one of the main causes of infection and damage of S. pneumoniae. Therefore, using pneumolysin as a target to study its inhibitors can provide a new treatment strategy for pneumococcal disease. This study analyzed the inhibitory effect of the natural compound hederagenin on PLY in vitro. The results show that hederagenin has great potential as a new strategy for the treatment of pneumococcal diseases. (c) 2021 Published by Elsevier Masson SAS on behalf of Institut Pasteur.
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收藏
页数：5
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