Properties of selenium nanoparticles stabilized by Lycium barbarum polysaccharide-protein conjugates obtained with subcritical water

被引：18
|
作者：
Zhang, Jixian [1 ]
Ji, Tao [1 ]
Yang, Xue [1 ]
Liu, Guoyan [1 ]
Liang, Li [1 ]
Liu, Xiaofang [1 ]
Wen, Chaoting [1 ]
Ye, Zhiqiang [1 ]
Wu, Maowei [1 ]
Xu, Xin [1 ]
机构：
[1] Yangzhou Univ, Coll Food Sci & Engn, Yangzhou 225127, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2022年 / 205卷
关键词：
Selenium nanoparticles; Polysaccharide-protein conjugates; Subcritical water; Stability; Antitumor activity; COMPLEXES; DEGRADATION; INDUCTION; APOPTOSIS;
D O I：
10.1016/j.ijbiomac.2022.02.165
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Selenium nanoparticles (SeNPs) in an aqueous solution have poor stability and tend to aggregate when stored for a long time. In the present study, SeNPs were stabilized by using Lycium barbarum polysaccharide (LBP) and Lycium barbarum protein (LBPr) conjugates (LBPP) as a stabilizer and dispersing agent. Particularly, the LBPP1 was obtained with subcritical water treatment. In addition, the physical stability, re-dispersity and antitumor activity of LBPP1-SeNPs were investigated. The results showed the particle size of LBPP1-SeNPs was maintained at 111.5-117 nm, which was stable at PH 6, 4 degrees C and darkness for at least 40 days. Besides, the result of TEM showed that the dispersion of LBPP1-SeNPs had more clear layers and smoother surfaces. Moreover, LBPP1-SeNPs had excellent re-dispersibility and exhibited a significant inhibitory effect on HepG-2 cells and Caco-2 cells, respectively (p < 0.05). Therefore, LBPP1-SeNPs can be used as potential selenium nutritional supplements for food and medical applications.
引用
收藏
页码：672 / 681
页数：10
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