Role of nitric oxide in genotoxicity: Implication for carcinogenesis

被引：117

作者：

Felley-Bosco, E ^{[1
]}

机构：

[1] Univ Lausanne, Inst Pharmacol & Toxicol, CH-1005 Lausanne, Switzerland

来源：

CANCER AND METASTASIS REVIEWS | 1998年 / 17卷 / 01期

关键词：

nitric oxide; peroxynitrite; inflammation; cancer; oxidative damage; mutations;

D O I：

10.1023/A:1005948420548

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Reactive oxygen species can initiate carcinogenesis by virtue of their capacity to react with DNA and cause mutations. Recently, it has been suggested that nitric oxide (NO) and its derivatives produced in inflamed tissues could contribute to the carcinogenesis process. Genotoxicity of NO follows its reaction with oxygen and superoxide. It can be due either to direct DNA damage or indirect DNA damage. Direct damage includes DNA base deamination, peroxynitrite-induced adducts formation and single strand breaks in the DNA. Indirect damage is due to the interaction of NO reactive species with other molecules such as amines, thiols and lipids. The efficiency of one pathway or another might depend on the cellular antioxidant status or the presence of free metals.

引用

页码：25 / 37

页数：13

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