Nobiletin Inhibits PDGF-BB-Induced Vascular Smooth Muscle Cell Proliferation and Migration and Attenuates Neointimal Hyperplasia in a Rat Carotid Artery Injury Model

被引：31

作者：

Guan, Siyu ^{[1
,2
]}

Tang, Qizhu ^{[1
]}

Liu, Wenwei ^{[2
]}

Zhu, Rui ^{[2
]}

Li, Bin ^{[2
]}

机构：

[1] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan 430060, Hubei Province, Peoples R China

[2] Hubei Univ Arts & Sci, Dept Cardiol, Xiangyang Cent Hosp, Hosp Affiliated, Xiangyang 441021, Peoples R China

来源：

DRUG DEVELOPMENT RESEARCH | 2014年 / 75卷 / 08期

关键词：

nobiletin; vascular smooth muscle cells; neointimal hyperplasia; artery injury; ACTIVATED PROTEIN-KINASE; OXIDATIVE STRESS; ELUTING STENTS; RESTENOSIS; THERAPY; ERK;

D O I：

10.1002/ddr.21230

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The abnormal migration and proliferation of vascular smooth muscle cells (VSMCs) plays a pivotal role in the development of neointimal hyperplasia after vascular injury. Nobiletin, a citrus bioflavonoid, exhibits anti-inflammatory and anti-oxidative activities. The present study evalutaed whether nobiletin could inhibit platelet-derived growth factor (PDGF)-BB- stimulated VSMC proliferation and migration and decrease neointimal hyperplasia in a rat carotid artery injury model. Cultured VSMCs from rat thoracic aortas were treated with nobiletin before being stimulated with 20ng/ml PDGF-BB, and rats were subjected to carotid artery injury. Nobiletin inhibited PDGF-BB-induced VSMC proliferation and migration, attenuated reactive oxygen species (ROS) production and reduced phosphorylation of ERK1/2 and the expression of nuclear NF-B p65 in PDGF-BB-stimulated VSMCs. Nobiletin decreased the intima area and the ratio of neointima to media in balloon-injured rat carotid arteries. Serum levels of TNF- and IL-6 in nobiletin-treated rats were decreased. These results indicated that nobiletin could be a potential protective agent for the prevention and treatment of restenosis after angioplasty. (C) 2014 Wiley Periodicals, Inc.

引用

页码：489 / 496

页数：8

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