The model of resting forms of micobacteria for testing of chemodrugs for latent forms of tuberculosis

被引：3

作者：

Anuchin, A. M. ^{[1
]}

Goncharenko, A. V. ^{[1
]}

Galon, I. V. ^{[1
]}

Demidenok, O. I. ^{[1
]}

Kudykina, Yu. K. ^{[1
]}

Moisenovich, M. M. ^{[2
]}

Mulyukin, A. L. ^{[3
]}

Kaprelyants, A. S. ^{[1
]}

机构：

[1] Russian Acad Sci, Bach Inst Biochem, Moscow 119071, Russia

[2] Moscow MV Lomonosov State Univ, Moscow 119991, Russia

[3] Vinogradsky Inst Microbiol, Moscow 117312, Russia

来源：

APPLIED BIOCHEMISTRY AND MICROBIOLOGY | 2010年 / 46卷 / 03期

关键词：

HISTONE-LIKE PROTEIN; MYCOBACTERIUM-SMEGMATIS;

D O I：

10.1134/S0003683810030063

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The new model of obtaining of ovoid resting forms of Mycobacterium smegmatis, which are morphologically different from vegetative (rod-like) cells, was developed. Ovoid forms were characterized by a drastically decreased level of metabolic activity, an increased stability to heat or antibiotics treatment, and also by prolonged (more than 2 months) storage time preserving colony-forming ability. Obtained resting forms of micobacteria may be used in test-systems for checking efficiency of new medical agents against latent forms of tuberculosis and determination of role of the genes in entering dormant state.

引用

页码：282 / 288

页数：7

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