Terephthalohydrazido cross-linked chitosan hydrogels: synthesis, characterization and applications

被引：18

作者：

Elmehbad, Noura Y. ^{[1
]}

Mohamed, Nadia A. ^{[2
,3
]}

机构：

[1] Najran Univ, Fac Sci & Arts, Dept Chem, Najran, Saudi Arabia

[2] Qassim Univ, Coll Arts & Sci, Dept Chem, Qasim, Saudi Arabia

[3] Cairo Univ, Dept Chem, Fac Sci, Giza, Egypt

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2022年 / 71卷 / 13期

关键词：

Antimicrobial activity; metal ions uptake; terephthalohydrazido chitosan hydrogels; swelling ability; RAPID COLORIMETRIC ASSAY; ANTIMICROBIAL ACTIVITY; METAL UPTAKE; IONS; BIOFILM; DERIVATIVES; ANTIBACTERIAL; ADSORPTION; SYSTEMS; GROWTH;

D O I：

10.1080/00914037.2021.1933975

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Two new hydrogels have been synthesized by incorporating terephthalohydrazido linkages into chitosan Schiff base (TCsSB) and chitosan (TCs). They swell at pH 4 more than at pH 9 and 7. TCs has a higher activity against most of the tested microbes as indicated from its lower MIC values than that measured by the reference drugs Vancomycin and Amphotericin B. Evaluation of the cytotoxicity impacts of TCsSB and TCs revealed that they are safe on normal cells of human. Their adsorption capacity toward some heavy metal ions could be arranged as follows: Co+2 > Ni+2 > Cu+2 > Cd+2 ions.

引用

页码：969 / 982

页数：14

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