Amino acid-based H2S donors: N-thiocarboxyanhydrides that release H2S with innocuous byproducts

被引：17

作者：

Kaur, Kuljeet ^{[1
,2
,3
,4
]}

Enders, Patrick ^{[1
,2
,5
]}

Zhu, Yumeng ^{[1
,2
]}

Bratton, Abigail F. ^{[1
,2
]}

Powell, Chadwick R. ^{[1
,2
]}

Kashfi, Khosrow ^{[6
]}

Matson, John B. ^{[1
,2
]}

机构：

[1] Virginia Tech, Virginia Tech Ctr Drug Discovery, Dept Chem, Blacksburg, VA 24061 USA

[2] Virginia Tech, Macromol Innovat Inst, Blacksburg, VA 24061 USA

[3] Ecole Polytech Fed Lausanne EPFL, Inst Mat, CH-1015 Lausanne, Switzerland

[4] Ecole Polytech Fed Lausanne EPFL, Lab Polymeres, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

[5] Rostock Univ, Inst Chem, Albert Einstein Str 3a, D-18059 Rostock, Germany

[6] CUNY, Sch Med, Dept Mol Cellular & Biomed Sci, New York, NY 10031 USA

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 45期

基金：

美国国家卫生研究院;

关键词：

HYDROGEN-SULFIDE DELIVERY; NITRIC-OXIDE; MOLECULE; COS;

D O I：

10.1039/d1cc01309b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H2S-release kinetics is reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing donors exhibiting the greatest cytotoxic effects.

引用

页码：5522 / 5525

页数：4

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