Syntheses and Immunological Evaluation of Self-Adjuvanting Clustered N-Acetyl and N-Propionyl Sialyl-Tn Combined with a T-helper Cell Epitope as Antitumor Vaccine Candidates

被引：25

作者：

Chang, Tsung-Che ^{[1
]}

Manabe, Yoshiyuki ^{[1
,2
]}

Fujimoto, Yukari ^{[3
]}

Ohshima, Shino ^{[4
]}

Kametani, Yoshie ^{[4
]}

Kabayama, Kazuya ^{[1
,2
]}

Nimura, Yuka ^{[1
]}

Lin, Chun-Cheng ^{[5
]}

Fukase, Koichi ^{[1
,2
]}

机构：

[1] Osaka Univ, Dept Chem, Grad Sch Sci, 1-1 Machikaneyama, Toyonaka, Osaka 5600043, Japan

[2] Osaka Univ, Core Med & Sci Collaborat Res & Educ, Project Res Ctr Fundamental Sci, 1-1 Machikaneyama, Toyonaka, Osaka 5600043, Japan

[3] Keio Univ, Dept Chem, Fac Sci & Technol, Kohoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan

[4] Tokai Univ, Sch Med, Fac Med, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan

[5] Natl Tsing Hua Univ, Dept Chem, 101 Sect 2,Kuang Fu Rd, Hsinchu 30013, Taiwan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 27期

关键词：

adjuvants; antigens; cancer vaccines; carbohydrates; sialyl-Tn; METASTATIC BREAST-CANCER; MUC1; GLYCOPEPTIDES; SUBCLASS RESTRICTION; PANCREATIC-CANCER; IMMUNE-RESPONSE; TUMOR-CELLS; SIALOSYL-TN; KLH VACCINE; ANTIBODIES; ACID;

D O I：

10.1002/anie.201804437

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sialyl-Tn (STn) is a tumor-associated carbohydrate antigen (TACA) rarely observed on healthy tissues. We synthesized two fully synthetic N-acetyl and N-propionyl STn trimer (triSTn) vaccines possessing a T-helper epitope and a TLR2 agonist, since the clustered STn antigens are highly expressed on many cancer cells. Immunization of both vaccines in mice induced the anti-triSTn IgG antibodies, which recognized triSTn-expressing cell lines PANC-1 and HepG2. The N-propionyl triSTn vaccine induced the triSTn-specific IgGs, while IgGs induced by the N-acetyl triSTn vaccine were less specific. These results illustrated that N-propionyl triSTn is a valuable unnatural TACA for anticancer vaccines.

引用

页码：8219 / 8224

页数：6

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