Clinical 18F-FDG and amyloid brain positron emission tomography/CT in the investigation of cognitive impairment: where are we now?

被引：9

作者：

Dumba, Maureen ^{[1
]}

Khan, Sairah ^{[2
]}

Patel, Neva ^{[2
,3
]}

Perry, Laura ^{[2
,3
]}

Malhotra, Paresh ^{[4
,5
]}

Perry, Richard ^{[4
,5
]}

Nijran, Kuldir ^{[2
,3
]}

Barwick, Tara ^{[2
]}

Wallitt, Kathryn ^{[2
]}

Win, Zarni ^{[2
]}

机构：

[1] Imperial Coll Healthcare NHS Trust, Dept Neuroradiol, London, England

[2] Imperial Coll Healthcare NHS Trust, Dept Nucl Med, London, England

[3] Imperial Coll Healthcare NHS Trust, Radiol Sci Unit, London, England

[4] Imperial Coll, Div Brain Sci, London, England

[5] Imperial Coll Healthcare NHS Trust, Dept Neurol, London, England

来源：

BRITISH JOURNAL OF RADIOLOGY | 2019年 / 92卷 / 1101期

关键词：

ALZHEIMERS-DISEASE; NATIONAL INSTITUTE; PET; DIAGNOSIS; DEMENTIA; FDG; ANGIOPATHY;

D O I：

10.1259/bjr.20181027

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The number of people living with dementia is increasing, but as yet there remains no cure or disease-modifying treatment. This review aims to help readers understand the role of F-18-FDG PET/CT imaging in the investigation of cognitive impairment and how the advent of amyloid PET/CT imaging may hold the key to radically changing management of the most common form of dementia - Alzheimer's disease. The indications for F-18-FDG PET/CT and amyloid PET/CT imaging in cognitive impairment are outlined. Additionally, the mechanisms of action, technique, patient preparation and acquisition parameters for both are detailed. We conclude by providing a framework for interpreting F-18-FDG PET/CT and amyloid PET/CT imaging in the more common conditions that lead to cognitive impairment conditions with tips on avoiding pitfalls in interpretation.

引用

页数：11

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