Unusual bioactive annonaceous acetogenins from Goniothalamus giganteus

被引：70

作者：

Alali, FQ ^{[1
]}

Rogers, L ^{[1
]}

Zhang, Y ^{[1
]}

McLaughlin, JL ^{[1
]}

机构：

[1] Purdue Univ, Sch Pharm & Pharmacal Sci, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 22期

关键词：

D O I：

10.1016/S0040-4020(98)00286-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyranicin (1) and pyragonicin (2) are the first mono-tetrahydropyran annonaceous acetogenins, and goniotrionin (3) possesses an unusual hydroxylated-allylic moiety. 1-3 were isolated from the bark of Goniothalamus giganteus using activity-directed fractionation with the brine shrimp lethality test. Both 1 and 2 are selectively cytotoxic against the pancreatic cell line (PACA-2) in a panel of six human solid tumor cell lines with 1 showing ten times the potency of adriamycin, while 3 showed more potent selectivity against the breast cell line (MCF-7). (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：5833 / 5844

页数：12

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