Design, synthesis and biological activity of 5-oxo-3(2H)-pyridazinone derivatives

被引：0

作者：

Ling, Yun ^{[1
]}

Li, Hong-Sen ^{[1
]}

Yang, Xin-Ling ^{[1
]}

Bao, Han ^{[1
]}

Qiu, Li-Hong ^{[1
]}

Chen, Fu-Heng ^{[1
]}

机构：

[1] China Agr Univ, Dept Appl Chem, Beijing 100094, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 27卷 / 06期

关键词：

3(2H)-pyridazinone; synthesis; biological activity; structure-activity relationship;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In order to search for new insect growth regulators, fifteen new compounds containing 5-oxo-3(2H)-pyridazinone derivatives were designed and synthesized. Their structures were confirmed by H-1 NMR, IR spectra and elemental analysis. In the preliminary bioassay test, compound 8o obviously disrupted the development of second-instar housefly larvae. Compounds 8a, 8c, 8g and 8j also showed good activity against the third-instar nymphs of locusts (Locusta migratoria manilensis). The structure-activity relationship of compounds was also discussed.

引用

页码：763 / 767

页数：5