Enoxacin-based derivatives: antimicrobial and antibiofilm agent: a biology-oriented drug synthesis (BIODS) approach

被引：2
|
作者：
Ahmed, Ayaz [1 ]
Khan, Anum Khalid [1 ]
Karim, Aneela [2 ]
Siddiqui, Rakhshinda [2 ]
Rafique, Rafaila [2 ]
Ali, Syed Abid [2 ]
Solangi, Mehwish [2 ]
Taha, Muhammad [3 ]
Khan, Khalid Mohammed [2 ,3 ]
机构：
[1] Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan
[2] Univ Karachi, Int Ctr Chem & Biol Sci ICCBS, HEJ Res Inst Chem, Karachi 75270, Pakistan
[3] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia
来源：
FUTURE MEDICINAL CHEMISTRY | 2022年 / 14卷 / 13期
关键词：
antibacterial; antibiofilm; derivatives; DNA-gyrases; enoxacin; fluorescence microscopy; Gram-negative; Gram-positive; spectroscopic analysis; synthesis; RESISTANT STAPHYLOCOCCUS-AUREUS; SCHIFF-BASES; ANTIBACTERIAL; ANTIFUNGAL; MECHANISMS; BIOFILMS; EFFICACY; GROWTH; GENES;
D O I：
10.4155/fmc-2022-0065
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Background: To find alternative molecules against Klebsiella pneumonia, Proteus mirabilis and methicillin-resistant Staphylococcus aureus, new enoxacin derivatives were synthesized and screened. Methods: All derivatives exhibited promising antibacterial activities as compared to standard enoxacin (2 mu g/ml) and standard cefixime (82 mu g/ml). Compounds 2, 3 and 5 significantly downregulated the gene expression of biofilm-forming genes. Conclusion: Based on our results, these molecules may serve as potential drug candidates to cure several bacterial infections in the future.
引用
收藏
页码：947 / 962
页数：16
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