Mitochondrial calcium channels

被引：74

作者：

Hoppe, Uta C. ^{[1
,2
]}

机构：

[1] Univ Cologne, Dept Internal Med 3, D-50937 Cologne, Germany

[2] Univ Cologne CMMC, Ctr Mol Med, Cologne, Germany

来源：

FEBS LETTERS | 2010年 / 584卷 / 10期

关键词：

Mitochondria; Calcium handling; Calcium channel; Mitochondrial calcium uniporter; Ryanodine receptor; CA2+ RELEASE CHANNELS; DEPENDENT ANION CHANNEL; RAT KIDNEY MITOCHONDRIA; HEART-MITOCHONDRIA; RYANODINE RECEPTOR; PERMEABILITY TRANSITION; ENDOPLASMIC-RETICULUM; NA+/CA2+ EXCHANGER; LIVER-MITOCHONDRIA; TRANSPORT;

D O I：

10.1016/j.febslet.2010.04.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial Ca2+ handling plays an important role in energy production and various cellular signaling processes. Mitochondrial Ca2+ uptake is regulated by the mitochondrial Ca2+ uniporter (MCU), at least one non- MCU Ca2+ channel and possibly a mitochondrial ryanodine receptor. Two distinct mechanisms mediate Ca2+ outward transport, the Na+-dependent (mNCX) and the Na+-independent Ca2+ efflux. In recent years we gained more insight into the regulation and function of these different Ca2+ transport mechanisms. However, the precise physiological role and the molecular structure of all mitochondrial Ca2+ transporters and channels still has to be determined. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1975 / 1981

页数：7

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