Functional responsiveness of memory T cells from COVID-19 patients

被引：24

作者：

Tavukcuoglu, Ece ^{[1
]}

Horzum, Utku ^{[1
]}

Inkaya, Ahmet Cagkan ^{[2
]}

Unal, Serhat ^{[2
]}

Esendagli, Gunes ^{[1
]}

机构：

[1] Hacettepe Univ, Dept Basic Oncol, Canc Inst, TR-06100 Ankara, Turkey

[2] Hacettepe Univ, Fac Med, Dept Infect Dis, Ankara, Turkey

来源：

CELLULAR IMMUNOLOGY | 2021年 / 365卷

关键词：

SARS-CoV-2; Central memory T cells; Effector memory T cells; Spike S1 glycoprotein; Dendritic cell; Helper T cells; Cytotoxic T lymphocytes;

D O I：

10.1016/j.cellimm.2021.104363

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The presence of memory T cells in COVID-19 patients has been acknowledged, however the functional potency of memory responses is critical for protection. In this study, naive, effector, effector memory, and central memory CD4(+) and CD8(+) T cells obtained from the COVID-19 survivors were re-exposed to autologous monocyte-derived DCs that were loaded with SARS-CoV-2 spike glycoprotein S1. Proliferation capacity, CD25, 4-1BB, and PD-1 expression, and IFN-gamma, IL-6, granzyme, granulysin, and FasL secretion were enhanced in CD4(+) and CD8(+) effector memory and central memory T cells. Albeit being at heterogeneous levels, the memory T cells from the individuals with COVID-19 history possess functional capacities to reinvigorate anti-viral immunity against SARS-CoV-2.

引用

页数：4

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