Argonaute proteins: structures and their endonuclease activity

被引：33
作者：
Jin, Shujuan [1 ]
Zhan, Jian [2 ]
Zhou, Yaoqi [1 ,2 ,3 ]
机构：
[1] Peking Univ, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China
[2] Griffith Univ, Inst Glyc, Brisbane, Qld, Australia
[3] Shenzhen Bay Lab, Inst Syst & Phys Biol, Shenzhen 518055, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2021年 / 48卷 / 05期
关键词：
Argonaute; MID domain; PIWI domain; Endonuclease; Guide; CRYSTAL-STRUCTURE; SMALL RNAS; GUIDE RNA; BACTERIAL ARGONAUTE; DNA INTERFERENCE; PAZ DOMAIN; PIWI; SLICER; GENOME; CLEAVAGE;
D O I：
10.1007/s11033-021-06476-w
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Argonaute proteins are highly conserved and widely expressed in almost all organisms. They not only play a critical role in the biogenesis of small RNAs but also defend against invading nucleic acids via small RNA or DNA-mediated gene silencing pathways. One functional mechanism of Argonaute proteins is acting as a nucleic-acid-guided endonuclease, which can cleave targets complementary to DNA or RNA guides. The cleavage then leads to translational silencing directly or indirectly by recruiting additional silencing proteins. Here, we summarized the latest research progress in structural and biological studies of Argonaute proteins and pointed out their potential applications in the field of gene editing.
引用
收藏
页码：4837 / 4849
页数：13
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