Piperidine Mediated Synthesis of N-Heterocyclic Chalcones and Their Antibacterial Activity

The chalcones 1-(2'-hydroxy-aryl)-3-(1-indol-3-yl)-prop-2-en-1-one (3) and 1-(2'-hydroxy-aryl)-3-(2-chloroquinolin-3-yl)-prop-2-en-1-one (6) were synthesised by piperidine mediated condensation of an ethanolic solution of an o-hydroxyacetophenone (1) with corresponding heteroaryl-3-carboxaldehyde. The structures have been established on the basis of elemental (C, H, N) analysis, UV, IR, (1)H NMR spectral data. The compounds 3 and 6 were screened for antimicrobial activities against a variety of bacterial agents.