Green Approach to the Synthesis of Polyfunctionalized Pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidines via Microwave-Assisted Multicomponent Reactions in Water Without Catalyst

被引：6

作者：

Shi, Feng ^{[1
]}

Ma, Ning ^{[1
]}

Zhou, Dianxiang ^{[1
]}

Zhang, Ge ^{[1
]}

Chen, Rongshun ^{[1
]}

Zhang, Yajie ^{[1
]}

Tu, Shujiang ^{[1
]}

机构：

[1] Xuzhou Normal Univ, Sch Chem & Chem Engn, Key Lab Biotechnol Med Plant, Xuzhou 221116, Jiangsu, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Green synthesis; microwave irradiation; pyrazolopyridopyrimidine; water; HETEROCYCLIC RING COMPOUNDS; ORGANIC-REACTIONS; SOLVENT;

D O I：

10.1080/00397910902962860

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A green approach to the synthesis of polyfunctionalized pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidines was successfully realized via multicomponent reactions of aldehydes, 3-methyl-1-phenyl-1H-pyrazol-5-amine, and 1-methylbarbituric acid in water under microwave irradiation without catalyst. This protocol has the prominent advantages of environmental friendliness, short reaction time, excellent yields, low cost, easy operation, and broad scope of applicability.

引用

页码：135 / 143

页数：9

共 21 条

[1]

Ahluwalia VK, 1996, INDIAN J CHEM B, V35, P1208

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