Control of Stimulus-Dependent Responses in Macrophages by SWI/SNF Chromatin Remodeling Complexes

被引：25
作者：
Gatchalian, Jovylyn [1 ]
Liao, Jingwen [1 ,2 ]
Maxwell, Matthew B. [1 ,2 ]
Hargreaves, Diana C. [1 ]
机构：
[1] Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USA
[2] Univ Calif San Diego, Biol Sci Program, La Jolla, CA 92037 USA
来源：
TRENDS IN IMMUNOLOGY | 2020年 / 41卷 / 02期
基金：
美国国家卫生研究院;
关键词：
INDUCIBLE GENE-EXPRESSION; KAPPA-B-ZETA; BAF COMPLEX; TRANSCRIPTION FACTORS; NUCLEAR-PROTEIN; CELL IDENTITY; ACTIVATION; BRG1; ENHANCERS; SUBUNIT;
D O I：
10.1016/j.it.2019.12.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Epigenetic regulation plays an important role in controlling the activation, timing, and resolution of innate immune responses in macrophages. Previously, SWI/SNF chromatin remodeling was found to define the kinetics and selectivity of gene activation in response to microbial ligands; however, these studies do not reflect a comprehensive understanding of SWI/SNF complex regulation. In 2018, a new variant of the SWI/SNF complex was identified with unknown function in inflammatory gene regulation. Here, we summarize the biochemical and genomic properties of SWI/SNF complex variants and the potential for increased regulatory control of innate immune transcriptional programs in light of such biochemical diversity. Finally, we review the development of SWI/SNF complex chemical inhibitors and degraders that could be used to modulate immune responses.
引用
收藏
页码：126 / 140
页数：15
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