Current progress in application of polymeric nanofibers to tissue engineering

被引：223

作者：

Nemati, Sorour ^{[1
,2
]}

Kim, Se-jeong ^{[1
,2
]}

Shin, Young Min ^{[3
,4
]}

Shin, Heungsoo ^{[1
,2
]}

机构：

[1] Hanyang Univ, Dept Bioengn, 222 Wangsimni Ro, Seoul 04763, South Korea

[2] BK21 Plus Future Biopharmaceut Human Resources Tr, 222 Wangsimni Ro, Seoul 04763, South Korea

[3] Dankook Univ, Dept Nanobiomed Sci, Cheonan 31116, South Korea

[4] Dankook Univ, Plus NBM Global Res Ctr Regenerat Med BK21, Cheonan 31116, South Korea

来源：

NANO CONVERGENCE | 2019年 / 6卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Tissue engineering; Extracellular matrix; Polymeric nanofibers; Electrospinning; Functional nanofibers; Tissue engineering applications; ELECTROSPUN NANOFIBERS; EXTRACELLULAR-MATRIX; PEPTIDE NANOFIBERS; CARDIAC TISSUE; DRUG-DELIVERY; SURFACE MODIFICATION; COMPOSITE SCAFFOLDS; FIBROUS SCAFFOLDS; PHASE-SEPARATION; CROSS-LINKING;

D O I：

10.1186/s40580-019-0209-y

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Tissue engineering uses a combination of cell biology, chemistry, and biomaterials to fabricate three dimensional (3D) tissues that mimic the architecture of extracellular matrix (ECM) comprising diverse interwoven nanofibrous structure. Among several methods for producing nanofibrous scaffolds, electrospinning has gained intense interest because it can make nanofibers with a porous structure and high specific surface area. The processing and solution parameters of electrospinning can considerably affect the assembly and structural morphology of the fabricated nanofibers. Electrospun nanofibers can be made from natural or synthetic polymers and blending them is a straightforward way to tune the functionality of the nanofibers. Furthermore, the electrospun nanofibers can be functionalized with various surface modification strategies. In this review, we highlight the latest achievements in fabricating electrospun nanofibers and describe various ways to modify the surface and structure of scaffolds to promote their functionality. We also summarize the application of advanced polymeric nanofibrous scaffolds in the regeneration of human bone, cartilage, vascular tissues, and tendons/ligaments.

引用

页数：16

共 157 条

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Agarwal S., 2015, NANOFIBERS ELECTROSP, P1

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