Design, Synthesis, Spectral Analysis, In Vitro Anticancer Evaluation and Molecular Docking Studies of Some Fluorescent 4-Amino-2, 3-Dimethyl-1-Phenyl-3-Pyrazolin-5-One, Ampyrone Derivatives

被引：14
作者：
Premnath, D. [1 ]
Enoch, Israel V. M. V. [2 ]
Selvakumar, P. Mosae [2 ]
Indiraleka, M. [3 ]
Vennila, J. Jannet [1 ]
机构：
[1] Karunya Univ, Sch Hlth Sci & Biotechnol, Dept Biotechnol, Coimbatore 641114, Tamil Nadu, India
[2] Karunya Univ, Sch Sci & Humanities, Dept Chem, Coimbatore 641114, Tamil Nadu, India
[3] Mepco Schlenk Engn Coll, Dept Biotechnol, Sivakasi, Tamil Nadu, India
来源：
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES | 2017年 / 9卷 / 01期
关键词：
4-Aminoantipyrine; Fluorescence spectroscopy; Molecular docking; Cytotoxic activity; CERVICAL-CANCER; COMPLEXES; ANTIPYRINE; CARCINOMA; APOPTOSIS; DRUGS; MODEL;
D O I：
10.1007/s12539-015-0138-3
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The commenced work deals with the synthesis, characterization and evaluation of biological activities of 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one. The synthesis was done by the condensation of aromatic acid chlorides with 4-aminoantipyrine. The structures of synthesized derivatives were elucidated using IR, Mass, H-1 NMR and C-13 NMR spectroscopy, and their UV-Visible and fluorescence properties were studied. The compounds showed significant dual fluorescence. Molecular docking was used to understand the small molecule-receptor protein interaction. The derivatives were screened for their in vitro cytotoxic activity against the reference drug pazopanib on human cervical cancer cell line (SiHa) using MTT assay.
引用
收藏
页码：130 / 139
页数：10
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