Mitochondrial dysfunction in Alzheimer's disease-a proteomics perspective

被引：36

作者：

Abyadeh, Morteza ^{[1
]}

Gupta, Vivek ^{[2
]}

Chitranshi, Nitin ^{[2
]}

Gupta, Veer ^{[3
]}

Wu, Yunqi ^{[4
]}

Saks, Danit ^{[2
]}

Wander Wall, Roshana ^{[2
]}

Fitzhenry, Matthew J. ^{[4
]}

Basavarajappa, Devaraj ^{[2
]}

You, Yuyi ^{[2
]}

Salekdeh, Ghasem H. ^{[5
]}

Haynes, Paul a ^{[5
]}

Graham, Stuart L. ^{[2
]}

Mirzaei, Mehdi ^{[2
]}

机构：

[1] ACECR, Royan Inst Stem Cell Biol & Technol, Dept Mol Syst Biol, Cell Sci Res Ctr, Tehran, Iran

[2] Macquarie Univ, Dept Clin Med, Macquarie Pk, NSW, Australia

[3] Deakin Univ, Sch Med, Geelong, Vic, Australia

[4] Macquarie Univ, Australian Proteome Anal Facil, Macquarie Pk, NSW, Australia

[5] Macquarie Univ, Dept Mol Sci, Macquarie Pk, NSW, Australia

来源：

EXPERT REVIEW OF PROTEOMICS | 2021年 / 18卷 / 04期

基金：

英国医学研究理事会;

关键词：

Proteomics; Alzheimer’ s disease; Mitochondrial dysfunction; AMYLOID-BETA-PEPTIDE; OXIDATIVE STRESS; COGNITIVE IMPAIRMENT; BRAIN MITOCHONDRIA; APOE GENOTYPE; PROTEIN DRP1; TG2576; MICE; TAU; DEMENTIA; ABNORMALITIES;

D O I：

10.1080/14789450.2021.1918550

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial dysfunction is involved in Alzheimer's disease (AD) pathogenesis. Mitochondria have their own genetic material; however, most of their proteins (similar to 99%) are synthesized as precursors on cytosolic ribosomes, and then imported into the mitochondria. Therefore, exploring proteome changes in these organelles can yield valuable information and shed light on the molecular mechanisms underlying mitochondrial dysfunction in AD. Here, we review AD-associated mitochondrial changes including the effects of amyloid beta and tau protein accumulation on the mitochondrial proteome. We also discuss the relationship of ApoE genetic polymorphism with mitochondrial changes, and present a meta-analysis of various differentially expressed proteins in the mitochondria in AD. Area covered: Proteomics studies and their contribution to our understanding of mitochondrial dysfunction in AD pathogenesis. Expert opinion: Proteomics has proven to be an efficient tool to uncover various aspects of this complex organelle, which will broaden our understanding of mitochondrial dysfunction in AD. Evidently, mitochondrial dysfunction is an early biochemical event that might play a central role in driving AD pathogenesis.

引用

页码：295 / 304

页数：10