Assay system for the herbicide 2,4-dichlorophenoxyacetic acid using a molecularly imprinted polymer as an artificial recognition element

被引：233
作者：
Haupt, K [1 ]
Dzgoev, A [1 ]
Mosbach, K [1 ]
机构：
[1] Univ Lund, Dept Pure & Appl Biochem, Ctr Chem, S-22100 Lund, Sweden
来源：
ANALYTICAL CHEMISTRY | 1998年 / 70卷 / 03期
关键词：
D O I：
10.1021/ac9711549
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Noncovalent molecular imprinting of a synthetic polymer with the herbicide 2,4-dichlorophenoxyacetic acid has been achieved in the presence of the polar solvents methanol and water. Formation of the prearranged complex relied on hydrophobic and ionic interactions between the template and the functional monomer 4-vinylpyridine. The polymer obtained binds the original template with an appreciable selectivity over structurally related compounds. The potential use of micrometer-sized imprinted polymer particles as the recognition element in a radioligand binding assay for 2,4-dichlorophenoxyacetic acid is demonstrated.
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页码：628 / 631
页数：4
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