Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands

被引：225
作者：
Cao, Yihai [1 ]
机构：
[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden
来源：
SCIENCE SIGNALING | 2009年 / 2卷 / 59期
关键词：
ENDOTHELIAL-GROWTH-FACTOR; FACTOR GENE-EXPRESSION; INHIBITS TUMOR-GROWTH; HIGH-AFFINITY BINDING; TYROSINE-KINASE; FACTOR-B; FACTOR RECEPTOR-1; SIGNAL-TRANSDUCTION; FACTOR-I; VASCULAR-PERMEABILITY;
D O I：
10.1126/scisignal.259re1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vascular endothelial growth factor-A (VEGF-A) is a key target for new antiangiogenic drugs for the treatment of both malignant and nonmalignant human diseases. Vascular effects of VEGF family members are mainly mediated by VEGF receptor 2 (VEGFR2). Conversely, the function and signaling of VEGFR1, which is present on endothelial and nonendothelial cells, are poorly understood. Intriguingly, two of five members in the VEGF family-VEGF-B and placental growth factor (PlGF)-are exclusive ligands for VEGFR1 and do not interact with the other VEGFRs, VEGFR2 and VEGFR3. These VEGFR1-specific ligands may be important therapeutic targets for the treatment of cancer. This Review discusses the distinctive roles of VEGFR1 and its ligands PlGF and VEGF-B in the mediation of angiogenic signaling and considers the therapeutic potential of targeting these particular vascular factors.
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页数：11
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