Retinal microglia polarization in diabetic retinopathy

被引：28

作者：

Li, Xin ^{[1
]}

Yu, Zi-Wei ^{[1
]}

Li, Hui-Yao ^{[1
]}

Yuan, Yue ^{[1
]}

Gao, Xin-Yuan ^{[1
]}

Kuang, Hong-Yu ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China

来源：

VISUAL NEUROSCIENCE | 2021年 / 38卷

关键词：

microglia polarization; retinal microglia; diabetic retinopathy;

D O I：

10.1017/S0952523821000031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microglia, the main immune cell of the central nervous system (CNS), categorized into M1-like phenotype and M2-like phenotype, play important roles in phagocytosis, cell migration, antigen presentation, and cytokine production. As a part of CNS, retinal microglial cells (RMC) play an important role in retinal diseases. Diabetic retinopathy (DR) is one of the most common complications of diabetes. Recent studies have demonstrated that DR is not only a microvascular disease but also retinal neurodegeneration. RMC was regarded as a central role in neurodegeneration and neuroinflammation. Therefore, in this review, we will discuss RMC polarization and its possible regulatory factors in early DR, which will provide new targets and insights for early intervention of DR.

引用

页数：7

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