Bone and Joint Disorders in Acromegaly

被引：69

作者：

Claessen, Kim M. J. A. ^{[1
,2
]}

Mazziotti, Gherardo ^{[3
]}

Biermasz, Nienke R. ^{[1
,2
]}

Giustina, Andrea ^{[3
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Endocrinol & Metab, C7-Q POB 9600, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Ctr Endocrine Tumors Leiden CETL, NL-2300 RC Leiden, Netherlands

[3] Univ Brescia, Endocrine Unit, Brescia, Italy

来源：

NEUROENDOCRINOLOGY | 2016年 / 103卷 / 01期

关键词：

Acromegaly; Growth hormone; Insulin-like growth factor 1; Vertebral fractures; Bone turnover; Bone mineral density; Arthropathy; Cartilage hypertrophy; QUALITY-OF-LIFE; GROWTH-FACTOR-I; RADIOLOGICAL SPINAL DEFORMITIES; VERTEBRAL FRACTURE ASSESSMENT; TERM BIOCHEMICAL CONTROL; MINERAL DENSITY; TRABECULAR BONE; POSTMENOPAUSAL WOMEN; GH DEFICIENCY; INCREASED PREVALENCE;

D O I：

10.1159/000375450

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acromegaly is a chronic, progressive disease caused by a growth hormone (GH)-producing pituitary adenoma, resulting in elevated GH and insulin-like growth factor 1 concentrations. Following appropriate therapy (surgery, radiotherapy and/or medical treatment), many systemic GH-induced comorbid conditions improve considerably. Unfortunately, despite biochemical control, acromegaly patients suffer from a high prevalence of late manifestations of transient GH excess, significantly impairing their quality of life. In this overview article, we summarize the pathophysiology, diagnosis, clinical picture, disease course and management of skeletal complications of acromegaly, focusing on vertebral fractures and arthropathy. (C) 2015 S. Karger AG, Basel

引用

页码：86 / 95

页数：10

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