Copper-Catalyzed Coupling of N-Tosylhydrazones with Amines: Synthesis of Fluorene Derivatives

被引：44

作者：

Aziz, Jessy ^{[1
]}

Frison, Gilles ^{[2
,3
]}

Gomez, Montserrat ^{[4
,5
]}

Brion, Jean-Daniel ^{[1
]}

Hamze, Abdallah ^{[1
]}

Alami, Mouad ^{[1
]}

机构：

[1] Univ Paris 11, Equipe Labellisee Ligue Canc, Lab Chim Therapeut, CNRS,BioCIS UMR 8076,LabEx LERMIT,Fac Pharm, F-92296 Chatenay Malabry, France

[2] Ecole Polytech, Dept Chem, Lab Chim Mol, F-91128 Palaiseau, France

[3] CNRS, F-91128 Palaiseau, France

[4] Univ Toulouse 3, UPS, Lab Heterochim Fondamentale & Appl, F-31062 Toulouse 9, France

[5] CNRS UMR 5069, F-31062 Toulouse 9, France

来源：

ACS CATALYSIS | 2014年 / 4卷 / 12期

关键词：

N-tosylhydrazones; C-N/C-C bond formation; autotandem catalysis; carbenoid; fluoren-9H-amines; DIAZO-COMPOUNDS; MIGRATORY INSERTION; BOND FORMATION; METAL CARBENE; PALLADIUM; CYCLIZATION; HYDRAZONES; REAGENTS;

D O I：

10.1021/cs5014877

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An original formation of one C-N bond and one C-C bond on the same carbenic center has been developed. This approach involves a copper-catalyzed cross-coupling reaction between 2'-bromo-biaryl-N-tosylhydrazones and different amines leading to 9H-fluoren-9-amine derivatives. This reaction proceeds under mild conditions in glycerol, an inexpensive and environmentally friendly solvent, without adding any external ligand.

引用

页码：4498 / 4503

页数：6

共 41 条

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