The BEST criteria improve sensitivity for detecting positive cultures in residual blood components cultured in suspected septic transfusion reactions

被引：10

作者：

Shih, Andrew W. ^{[1
,2
]}

Cohn, Claudia S. ^{[3
]}

Delaney, Meghan ^{[4
]}

Fontaine, Magali J. ^{[5
]}

Martin, Isabella ^{[6
]}

Dunbar, Nancy M. ^{[6
]}

Dagger, John ^{[7
]}

Fadeyi, Emmanuel A. ^{[8
]}

Flanagan, Peter ^{[7
]}

Gathof, Birgit ^{[9
]}

Godbey, Elizabeth A. ^{[10
]}

Harach, Mary ^{[11
]}

Huggins, Y. Monique ^{[12
]}

Ipe, Tina S. ^{[13
]}

Jackson, Bryon ^{[14
]}

Jacquot, Cyril ^{[15
]}

Jin, Zhongbo ^{[12
]}

Jones, Mary Rose ^{[8
]}

Kamel, Hany ^{[16
]}

Karp, Julie K. ^{[11
]}

Lewin, Antoine ^{[17
]}

Mo, Yunchuan ^{[15
]}

Murphy, Mike ^{[18
]}

O'Brien, Jennifer ^{[19
]}

Ommer, Katharina ^{[9
]}

Pagano, Monica B. ^{[20
]}

Passwater, Michael ^{[21
]}

Pelletier, J. Peter R. ^{[12
]}

Robillard, Pierre ^{[17
]}

Schwartz, Joseph ^{[10
]}

Sham, Lawrence ^{[22
]}

Shunkwiler, Sara M. ^{[23
]}

Simmons, Julie S. ^{[8
]}

Staves, Julie ^{[18
]}

Takanaski, Minoko ^{[24
]}

Vasallo, Ralph ^{[16
]}

Weiss, Susan ^{[21
,25
]}

Williams, Shelly M. ^{[26
]}

Yamada, Chisa ^{[27
]}

Young, Pampee P. ^{[28
]}

Ziman, Alyssa ^{[29
]}

机构：

[1] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada

[2] Vancouver Coastal Hlth Author, Vancouver, BC, Canada

[3] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[4] Childrens Natl Hlth Syst, Dept Pathol & Lab Med, Washington, DC USA

[5] Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA

[6] Dartmouth Hitchcock Med Ctr, Dept Pathol & Lab Med, Lebanon, NH 03766 USA

[7] New Zealand Blood Serv, Wellington, New Zealand

[8] Wake Forest Baptist Univ, Med Ctr, Winston Salem, NC USA

[9] Univ Hosp Cologne, Cologne, Germany

[10] Columbia Univ, Irvine Med Ctr, New York, NY USA

[11] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA

[12] Univ Florida, Gainesville, FL USA

[13] Houston Methodist Hosp, Houston, TX USA

[14] Grady Mem Healthcare, Atlanta, GA USA

[15] Childrens Natl Hlth Syst, Washington, DC USA

[16] Vitalant, Scottsdale, AZ USA

[17] Hema Quebec, Montreal, PQ, Canada

[18] Oxford Univ Hosp, Oxford, England

[19] Univ Maryland, Baltimore, MD 21201 USA

[20] Univ Washington, Seattle, WA 98195 USA

[21] Vidant Med Ctr, Greenville, NC USA

[22] Vancouver Gen Hosp, Vancouver, BC, Canada

[23] Univ Nebraska Med Ctr, Omaha, NE USA

[24] Japanese Red Cross, Tokyo, Japan

[25] East Carolina Univ, Greenville, NC 27858 USA

[26] Univ Minnesota, Minneapolis, MN USA

[27] Univ Michigan, Ann Arbor, MI 48109 USA

[28] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA

[29] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

TRANSFUSION | 2019年 / 59卷 / 07期

关键词：

TRANSMITTED BACTERIAL-INFECTION; PLATELETS; RISK;

D O I：

10.1111/trf.15317

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Culturing residual blood components after suspected septic transfusion reactions guides management of patients and cocomponents. Current practice, accuracy of provider vital sign assessment, and performance of the AABB culture criteria are unknown. A multicenter international study was undertaken to investigate these issues and develop improved culture criteria. STUDY DESIGN AND METHODS: Retrospective data for all transfusion reactions resulting in residual blood component culture in 2016 were collected from participating hospitals. The performance of the AABB culture criteria were assessed for detection of positive culture results. Modifications to the AABB criteria including 1) recommending culturing in the setting of isolated high fevers, 2) defining hypotension and tachycardia using objective parameters, and 3) incorporating antipyretic use were tested to determine if modifications improved performance. Modifications associated with improvement were incorporate into the BEST criteria. The AABB and the BEST criteria were then tested against a data set enriched for positive culture results to determine which criteria were superior. RESULTS: Data were collected from 20 centers encompassing 779,143 transfusions, 3,187 reported transfusion reactions, and 1,104 cultured components. There was marked variation in reaction reporting and culturing rates (0.0%-100.0%). Of 35 total positive component cultures, only one of 35 (2.9%) had concordant patient cultures; 12 of 34 (35.3%) did not have patient cultures performed. The BEST criteria had better sensitivity for detection of a positive culture result compared to the AABB criteria (74% vs. 41%), although specificity decreased (45% vs. 65%). CONCLUSION: Compared to the AABB criteria, the BEST criteria have improved sensitivity for positive culture detection.

引用

页码：2292 / 2300

页数：9

共 14 条

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