Effects of tris(2-butoxyethyl) phosphate exposure on endocrine systems and reproduction of zebrafish (Danio rerio)

被引：55

作者：

Kwon, Bareum ^{[1
,2
]}

Shin, Hyejin ^{[3
]}

Moon, Hyo-Bang ^{[4
]}

Ji, Kyunghee ^{[1
]}

Kim, Ki-Tae ^{[3
]}

机构：

[1] Yongin Univ, Grad Sch, Dept Environm Hlth, Yongin 17092, South Korea

[2] Croen Res Inc, CRI Global Inst Toxicol, Suwon 16614, South Korea

[3] Seoul Natl Univ Sci & Technol, Dept Environm Engn, Seoul 01811, South Korea

[4] Hanyang Univ, Dept Marine Sci & Convergent Technol, Ansan 15588, South Korea

来源：

ENVIRONMENTAL POLLUTION | 2016年 / 214卷

基金：

新加坡国家研究基金会;

关键词：

TBEOP; Organophosphate flame retardants; Endocrine disruption; HPG axis; Zebraflsh; ORGANOPHOSPHORUS FLAME RETARDANTS; POLYBROMINATED DIPHENYL ETHERS; DISRUPTING COMPOUNDS; MASS-SPECTROMETRY; DRINKING-WATER; AXIS; EXPRESSION; HORMONES; PHARMACEUTICALS; EMBRYOS/LARVAE;

D O I：

10.1016/j.envpol.2016.04.049

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Tris(2-butoxyethyl) phosphate (TBEOP), a widely used organophosphate flame retardant, has frequently been detected both in the environment and the biota. However, limited information is available on the effects of TBEOP on the endocrine system and its underlying mechanisms. We exposed adult zebrafish pairs to TBEOP at concentrations of 0, 2.1,11, and 118 mu g/L for 21 d, and investigated the effects on gene transcription and hormone production related to the hypothalamic-pituitary-gonadal (HPG) axis, and on reproduction. The adverse effects on the F1 generation were further examined. In male fish, plasma concentrations of 17 beta-estradiol were significantly increased along with up-regulation of cyp19a. Exposure to TBEOP at 118 mu g/L to a significant decrease in average egg production. Exposure of the F0 generation to TBEOP delayed hatching and lowered hatching rates in the F1 generation. The results demonstrate that exposure to TBEOP at environmentally relevant concentration levels could affect the sex hormone balance by altering regulatory circuits of the HPG axis, eventually leading to disruption of reproductive performance and the development of offspring. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：568 / 574

页数：7

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