Bilateral giant cell central granuloma of the jaws in a Noonan syndrome: About one case with emphasizing on bone giant cell lesions of the jaws

被引：1
作者：
Sizaret, Damien [1 ]
Tallegas, Matthias [1 ]
de Pinieux, Gonzague [1 ]
机构：
[1] CHRU Tours, Hop Trousseau, Serv Anat & Cytol Pathol, Ave Republ Chambray Les Tours, F-37044 Tours 9, France
来源：
ANNALES DE PATHOLOGIE | 2022年 / 42卷 / 03期
关键词：
Noonan syndrome; Central giant cell granuloma of the jaws; Multifocality; Brown tumor; Hyperparathyroidism; RASopathies; Cherubism;
D O I：
10.1016/j.annpat.2022.01.003
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
We report the case of a 10-year-old child with bilateral mandibular localization of a central giant cell granuloma occurring in the setting of Noonan syndrome. The histological appearance was classic with two intermigled components, one fibrous with non-atypical mono -nuclear cells, the other consisting of numerous osteoclast-like giant cells. This aspect is similar to that observed in the brown tumor as well as that of cherubism, which can also give multiple bone lesions. We will discuss the other lesions to consider in case of benign giant cell bone lesions affecting the jawbones, sometimes multiple and part of which falls within the scope of RASopathies. (c) 2022 Elsevier Masson SAS. All rights reserved.
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收藏
页码：259 / 263
页数：5
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