Variation in SLC1A1 is related to combat-related posttraumatic stress disorder

被引：5

作者：

Zhang, Jingmei ^{[1
]}

Sheerin, Christina ^{[4
]}

Mandel, Howard ^{[2
]}

Banducci, Anne N. ^{[5
]}

Myrick, Hugh ^{[1
,2
]}

Acierno, Ronald ^{[1
,2
]}

Amstadter, Ananda B. ^{[3
]}

Wang, Zhewu ^{[1
,2
]}

机构：

[1] Med Univ S Carolina, Dept Psychiat, Charleston, SC 29425 USA

[2] Ralph H Johnson VA Med Ctr, Charleston, SC USA

[3] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA

[4] McGuire VA Med Ctr, Richmond, VA USA

[5] Univ Maryland, Ctr Addict Personal & Emot Res, College Pk, MD 20742 USA

来源：

JOURNAL OF ANXIETY DISORDERS | 2014年 / 28卷 / 08期

关键词：

Posttraumatic stress disorder; SLC1A1; Combat stress disorders; Genes; Veterans; OBSESSIVE-COMPULSIVE DISORDER; GENOME-WIDE ASSOCIATION; ENVIRONMENTAL CONTRIBUTIONS; TRAUMA EXPOSURE; GENERATIONS; PTSD; SYMPTOMS; TWIN; GLUTAMATE; SAMPLE;

D O I：

10.1016/j.janxdis.2014.09.013

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Candidate gene studies have yet to investigate the glutamate system, the primary excitatory neurotransmitter of the HPA-axis related to PTSD risk. We investigated 13 SNPs in the glutamate transporter gene (SLC1A1) in relation to PTSD among combat-exposed veterans. Participants (n = 418) completed a diagnostic interview and provided a blood sample for DNA isolation and genotyping. A subset of participants (n = 391) had severity and combat exposure data available. In the primary logistic regression gender and rsl 0739062 were significant predictors of PTSD diagnosis (OR = 0.50; OR = 1.43). In the linear regression analysis, combat exposure was the only significant predictor (beta = 0.16) of severity. A computed genetic risk sum score was significant in relation to PTSD diagnosis (OR = 1.15) and severity scores (beta = 0.14) above and beyond the effects of combat exposure. This study provides preliminary support for the relationship of glutamate transporter polymorphisms to PTSD risk and the need for further genetic studies within this system. Published by Elsevier Ltd:

引用

页码：902 / 907

页数：6

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