Highly enantioselective synthesis of 3-hydroxy-2-methylpropanoic acid esters through ruthenium-SYNPHOS®-catalyzed hydrogenation:: Useful building blocks for the synthetic community

被引：19

作者：

Jeulin, Severine ^{[1
]}

Ayad, Tahar ^{[1
]}

Ratovelomanana-Vidal, Virginie ^{[1
]}

Genet, Jean-Pierre ^{[1
]}

机构：

[1] Ecole Natl Super Chim Paris, Lab Synth Select Organ & Produits Nat, CNRS, UMR 7573, F-75231 Paris 05, France

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 10期

关键词：

D O I：

10.1002/adsc.200700025

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Both enantiomers of 3-hydroxy-2-methylpropanoic acid tert-butyl ester were prepared with high enantioselectivity (up to 94%) through a ruthenium-SYNPHOS (R)-promoted asymmetric hydrogenation reaction using an atom-economic transformation from simple and inexpensive precursors.

引用

页码：1592 / 1596

页数：5

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