The efficacy of methylene blue encapsulated in silica nanoparticles compared to naked methylene blue for photodynamic applications

被引：10

作者：

Makhadmeh, Ghaseb Naser ^{[1
,3
]}

Aziz, Azlan Abdul ^{[1
,3
]}

Razak, Khairunisak Abdul ^{[2
,3
]}

机构：

[1] Univ Sains Malaysia, Sch Phys, Dept Phys, Usm 11800, Penang, Malaysia

[2] Univ Sains Malaysia, Dept Engn, Sch Mat & Mineral Resources Engn, Usm 11800, Penang, Malaysia

[3] Univ Sains Malaysia, Inst Res Mol Med INFORMM, NanoBiotechnol Res & Innovat NanoBRI, Usm 11800, Penang, Malaysia

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 03期

关键词：

encapsulation; half-life time; methylene blue; photodynamic therapy; silica nanoparticles;

D O I：

10.3109/21691401.2015.1008511

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background/Aims: This study analyzed the physical effects of methylene blue (MB) encapsulated within silica nanoparticles (SiNPs) in photodynamic therapy. Materials and methods: The optimum concentration of MB needed to destroy red blood cells (RBCs) was determined, and the efficacy of encapsulated MB-SiNPs compared to that of naked MB was verified. Results: The results confirmed the applicability of MB encapsulated in SiNPs on RBCs, and established a relationship between the concentration of the SiNP-encapsulated MB and the time required to rupture 50% of the RBCs (t(50)). Conclusion: The MB encapsulated in SiNPs exhibited higher efficacy compared to that of naked MB.

引用

页码：1018 / 1022

页数：5

共 9 条

[1]

Al-Akhras M. -A. H., 2013, J MOL PHARM ORG PROC, V1, P1

[2]

Bharali DJ, 2005, P NATL ACAD SCI USA, V102, P11539, DOI 10.1073/pnas.0504926102

[3] Nanoparticles in photodynamic therapy: An emerging paradigm [J].