Mussel-Inspired Thermoresponsive Polypeptide-Pluronic Copolymers for Versatile Surgical Adhesives and Hemostasis

被引：74

作者：

Lu, Dedai ^{[1
]}

Wang, Hongsen ^{[1
]}

Li, Ting'e ^{[1
]}

Li, Yunfei ^{[1
]}

Dou, Fajuan ^{[1
]}

Sun, Shaobo ^{[2
]}

Guo, Hongyun ^{[3
]}

Liao, Shiqi ^{[3
]}

Yang, Zhiwang ^{[1
]}

Wei, Qiangbing ^{[1
]}

Lei, Ziqiang ^{[1
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Polymer Mat Gansu Prov, Key Lab Ecoenvironm Related Polymer Mat,Minist Ed, Lanzhou 730070, Peoples R China

[2] Gansu Univ Chinese Med, Sch Basic Med Sci, Lanzhou 730000, Peoples R China

[3] Gansu Prov Canc Hosp, Inst Gansu Med Sci Res, Lanzhou 730050, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 20期

基金：

中国国家自然科学基金;

关键词：

polypeptide; thermoresponsive; mussel-inspired; biocompatible; surgical adhesive; BIOINSPIRED CATECHOLIC COPOLYMERS; GUANIDINIUM ION PENDANTS; DENDRITIC MOLECULAR GLUE; TISSUE ADHESIVE; CROSS-LINKING; BIOMEDICAL APPLICATIONS; OLIGO(ETHYLENE GLYCOL); MIMETIC POLYMER; HYDROGELS; CHEMISTRY;

D O I：

10.1021/acsami.6b16575

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Inspired by marine mussel adhesive proteins, polymers with catechol side groups have been extensively explored in industrial and academic research. Here, Pluronic L-31 alcoholate ions were used as the initiator to prepare a series of polypeptide Pluronic polypeptide triblock copolymers via ring-opening polymerization of L-DOPA-N-carboxyanhydride (DOPA-NCA), L-arginine-NCA (Arg-NCA), L-cysteine-NCA (CysNCA), and epsilon-N-acryloyl lysine-NCA (Ac-Lys-NCA). These copolymers demonstrated good biodegradability, biocompatibility, and thermoresponsive properties. Adhesion tests using porcine skin and bone as adherends demonstrated lap-shear adhesion strengths up to 106 kPa and tensile adhesion strengths up to 675 kPa. The antibleeding activity and tissue adhesive ability were evaluated using a rat model. These polypeptide Pluronic copolymer glues showed superior hemostatic properties and superior effects in wound healing and osteotomy gaps. Complete healing of skin incisions and remodeling of osteotomy gaps were observed in all rats after 14 and 60 days, respectively. These copolymers have potential uses as tissue adhesives, antibleeding, and tissue engineering materials.

引用

页码：16757 / 16767

页数：11

共 69 条

[1] Caddisfly Inspired Phosphorylated Poly(ester urea)-Based Degradable Bone Adhesives [J].