The human heart endothelin system: ET-1 synthesis, storage, release and effect

被引：64
作者：
Russell, FD
Molenaar, P
机构：
[1] Department of Medicine, Univ. Queensland, Prnc. Charles H., Chermside
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2000年 / 21卷 / 09期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S0165-6147(00)01524-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Endothelin-1 (ET-1) is synthesized, stared and released in the human heart. On release, ET-1 has the potential to activate specific receptors in a paracrine manner to modify heart function directly. Two binding sites corresponding to endothelin ETA and ETB receptors are localized to human heart. Contractility is modified by ETA receptors in the left ventricle and by ETA and ETB receptors, and a receptor that is possibly a difference on formation of ETA and/or ETB receptors, in the right atrium. The endothelin system might directly support the failing heart but might also contribute to its pathology, providing a basis for the therapeutic use of endothelin receptor antagonists.
引用
收藏
页码：353 / 359
页数：9
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