Do transmembrane protein superfolds exist?

被引：154

作者：

Jones, DT ^{[1
]}

机构：

[1] Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England

来源：

FEBS LETTERS | 1998年 / 423卷 / 03期

关键词：

transmembrane protein; protein structure prediction; protein superfold;

D O I：

10.1016/S0014-5793(98)00095-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A reliable and widely used transmembrane protein structure prediction algorithm was applied to five representative genomic sequence data sets in order to re-examine the hypothesis that in contrast to globular proteins there are no favored transmembrane protein fold families. When the number of predicted membrane spanning segments and the topology of these segments is taken into account then definite biases are observed which suggest that certain transmembrane topologies are significantly more common than others. (C) 1998 Federation of European Biochemical Societies.

引用

页码：281 / 285

页数：5

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