Nanostructured DNA for the delivery of therapeutic agents

被引：24

作者：

Nishikawa, Makiya ^{[1
]}

Tan, Mengmeng ^{[1
,2
]}

Liao, Wenqing ^{[1
,2
]}

Kusamori, Kosuke ^{[1
]}

机构：

[1] Tokyo Univ Sci, Fac Pharmaceut Sci, Tokyo 162, Japan

[2] Kyoto Univ, Grad Sch Pharmaceut Sci, Kyoto, Japan

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2019年 / 147卷

关键词：

DNA; Chemical modification; Electric charge; DNA nanotechnology; Protein binding; Cellular uptake; ROLLING CIRCLE AMPLIFICATION; X-RAY-SCATTERING; Y-SHAPED DNA; SCAVENGER RECEPTORS; NUCLEIC-ACIDS; CHEMICAL-MODIFICATIONS; IMMUNOSTIMULATORY DNA; CELLULAR UPTAKE; STRANDED-RNA; CPG-MOTIF;

D O I：

10.1016/j.addr.2019.09.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

DNA and RNA, the nucleic acids found in every living organism, are quite crucial, because not only do they store the genetic information, but also they are used as signals through interaction with various molecules within the body. The nature of nucleic acids, especially DNA, to form double-helix makes it possible to design nucleic acid-based nanostructures with various shapes. Because the shapes as well as the physicochemical properties determine their interaction with proteins or cells, nanostructured DNAs will have different features in the interaction compared with single- or double-stranded DNA. Some of these unique features of nanostructured DNA make ways for efficient delivery of therapeutic agents to specific targets. In this review, we begin with the factors affecting the properties of nanostructured DNA, followed by summarizing the methods for the development of nanostructured DNA. Further, we discuss the characteristics of nanostructured DNA and their applications for the delivery of bioactive compounds. (C) 2019 Published by Elsevier B.V.

引用

页码：29 / 36

页数：8

共 88 条

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