V600E BRAF mutation in pilocytic astrocytoma is associated with a more diffuse growth pattern but does not confer a more aggressive clinical behavior

被引：12

作者：

Bannykh, Sergei I. ^{[1
,2
]}

Mirocha, James ^{[3
]}

Nuno, Miriam ^{[4
]}

Lopategui, Jean ^{[1
,2
]}

Kandala, Gokul ^{[1
,2
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Pathol, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Dept Lab Med, Los Angeles, CA 90048 USA

[3] Cedars Sinai Med Ctr, Biostat Res Inst, Los Angeles, CA 90048 USA

[4] Cedars Sinai Med Ctr, Dept Neurosurg, Maxine Dunitz Neurosurg Inst, Ctr Neurosurg Outcomes Res, Los Angeles, CA 90048 USA

来源：

CLINICAL NEUROPATHOLOGY | 2014年 / 33卷 / 06期

关键词：

pilocytic; astrocytoma; BRAF; V600E; prognosis; MAPK PATHWAY ACTIVATION; LOW-GRADE ASTROCYTOMAS; FUSION GENE; GLIOMAS; DUPLICATION; FREQUENT; TUMORS; MECHANISM; 7Q34; CEREBELLAR;

D O I：

10.5414/NP300753

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Activation in mitogen activated protein kinase signaling pathway has recently been described as a predominant event in pilocytic astrocytoma (PA) and is commonly caused by constitutively active mutation in BRAF protein. Whereas PA of posterior fossa in children have a high prevalence of BRAF duplication and fusion, primary molecular abnormalities in supratentorial tumors of adults are more diverse and also include BRAF V600E point mutation. In our study we evaluated 51 PAs for BRAF duplication and BRAF V600E point mutation. We found a relatively high frequency of V600E mutation in our cohort. Histologically, V600E-carrying PA appeared more infiltrative, yet our limited clinical follow-up failed to detect a deleterious prognostic significance.

引用

页码：388 / 398

页数：11

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