Four-Component Domino Reaction Providing an Easy Access to Multifunctionalized Tricyclo[6.2.2.01,6]dodecane Derivatives

被引：93

作者：

Jiang, Bo ^{[1
,2
]}

Li, Chao ^{[1
]}

Shi, Feng ^{[1
]}

Tu, Shu-Jiang ^{[1
,2
]}

Kaur, Parminder ^{[3
]}

Wever, Walter ^{[3
]}

Li, Guigen ^{[3
]}

机构：

[1] Xuzhou Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Jiangsu, Peoples R China

[2] Suzhou Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Jiangsu, Peoples R China

[3] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 09期

基金：

美国国家科学基金会;

关键词：

ONE-POT; CASCADE; ACID;

D O I：

10.1021/jo1002278

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel four-component domino reaction has been discovered. The reaction is easy to perform simply by mixing four common reactants and Cs2CO3 in ethylene glycol under microwave heating. The reaction proceeds at fast rates and can be finished within 15-24 min, which makes workup convenient. Four stereogenic centers with one quaternary carbon amino function have been controlled completely. The stereochemistry has been unequivocally determined by X-ray structural analysis. The resulting tricyclo[6.2.2.0(1,6)]dodecane derivatives are of importance for organic and medicinal research.

引用

页码：2962 / 2965

页数：4

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