Counter-Current Chromatography Separation of Isatin Derivatives using the Sandmeyer Methodology

被引：20

作者：

Almeida, Marcia R. ^{[1
]}

Leitao, Gilda G. ^{[2
]}

Silva, Barbara V. ^{[1
]}

Barbosa, Jussara P. ^{[3
]}

Pinto, Angelo C. ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Quim, Ctr Tecnol, Ilha Fundao, BR-21941909 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Ctr Ciencias Saude, Nucleo Pesquisas Prod Nat, Ilha Fundao, BR-21941590 Rio De Janeiro, Brazil

[3] Inst Oswaldo Cruz, Lab Taxon Bioquim & Prospeccao Fungos, Fundacao Oswaldo Cruz, BR-21949900 Rio De Janeiro, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2010年 / 21卷 / 04期

关键词：

isatins; Sandmeyer methodology; isomers separation; counter-current chromatography; INHIBITORS; SYNTHASE;

D O I：

10.1590/S0103-50532010000400025

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rapid and efficient method, using high-speed counter-current chromatography (HSCCC) technique, was developed for the separation of isomeric isatin derivatives, prepared following the Sandmeyer route. The biphasic solvent system composed of hexane: ethyl acetate: ethanol: water 1:0.5:0.5:1 (v/v/v/v) was used for all separations.

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页码：764 / 769

页数：6

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