Intracerebroventricular injection of neuropeptide EI increases serum LH in male and female rats

被引：16
作者：
Attademo, AM
Sánchez-Borzone, M
Lasaga, M
Celis, ME [1 ]
机构：
[1] Univ Nacl Cordoba, Fac Med, Dept Farmacol, Lab Ciencias Fisiol, RA-5000 Cordoba, Argentina
[2] Univ Buenos Aires, Fac Med, Ctr Invest Reprod, RA-1112 Buenos Aires, DF, Argentina
来源：
PEPTIDES | 2004年 / 25卷 / 11期
关键词：
LH release; neuropeptide EI (NEI); intracerebroventricular (icv) injection; male and female rats; ovariectomized rats;
D O I：
10.1016/j.peptides.2004.06.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Melanin concentrating hormone (MCH) precursor-derived neuropeptide El (NEI) has not yet been extensively studied. The aim of this study was to determine the effect of neuropeptide El on serum levels of LH in normal male rats and chronically ovariectomized (CHR-OVX) female rats treated with estrogen benzoate (EB) and with a low dose of progesterone. The peptide, administered intracerebroventricularly in male and chronically ovariectomized female rats, increased LH serum levels compared to the controls injected with artificial cerebrospinal fluid. It is important to note that there is some relation between neuropeptide EI-melanin concentrating hormone and a-melanocyte stimulating hormone (alpha-MSH) indicating that all three peptides are associated in a complex inter-relationship. Therefore, the question that arises is if neuropeptide EI could also be related with the receptors for melanin concentrating hormone or alpha-melanocyte stimulating hormone. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：1995 / 1999
页数：5
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