Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine

被引：20

作者：

Borjigin, Liushiqi ^{[1
]}

Shimazu, Tomoyuki ^{[1
]}

Katayama, Yuki ^{[1
]}

Li, Meihua ^{[1
]}

Satoh, Takumi ^{[1
]}

Watanabe, Kouichi ^{[1
]}

Kitazawa, Haruki ^{[1
]}

Roh, Sang-gun ^{[1
]}

Aso, Hisashi ^{[1
]}

Katoh, Kazuo ^{[1
]}

Uchida, Takafumi ^{[1
]}

Suda, Yoshihito ^{[2
]}

Sakuma, Akiko ^{[3
]}

Nakajo, Mituru ^{[3
]}

Suzuki, Keiichi ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr Sci, 1-1 Tsutsumidori Amemiyamachi, Sendai, Miyagi 9818555, Japan

[2] Miyagi Univ, Dept Food Agr & Environm, Sendai, Miyagi, Japan

[3] Miyagi Prefecture Anim Ind Expt Stn, Sendai, Miyagi, Japan

来源：

ANIMAL SCIENCE JOURNAL | 2016年 / 87卷 / 03期

关键词：

disease resistance; immunogenic properties; mycoplasma pneumonia lesions; pig; GROWTH-HORMONE GH; T-CELLS; HYOPNEUMONIAE; EXPRESSION; BLOOD; PROLIFERATION; INDUCTION; INFECTION; RESPONSES; GHRELIN;

D O I：

10.1111/asj.12440

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Mycoplasma pneumonia of swine (MPS) lung lesions and immunogenic properties were compared between a Landrace line that was genetically selected for reduced incidence of pulmonary MPS lesions, and a non-selected Landrace line. The MPS-selected Landrace line showed significantly lower degrees of pulmonary MPS lesions compared with the non-selected Landrace line. When changes in immunity before and after vaccination were compared, the percentage of B cells in the peripheral blood of the MPS-selected Landrace line was significantly lower than that of the non-selected line. Furthermore, the concentration of growth hormone and the mitogen activity of peripheral blood mononuclear cells in the MPS-selected Landrace line showed significantly (P<0.05) lower increases after vaccination than the non-selected line. Conversely, the concentration of peripheral blood interferon (IFN)- and salivary immunoglobulin A (IgA) after Mycoplasma hyopneumoniae vaccination was significantly higher in the MPS-selected Landrace line than in the non-selected line. Gene expression of toll-like receptor (TLR)2 and TLR4 was significantly higher in the MPS-selected Landrace line in immune tissues, with the exception of the hilar lymph nodes. The present results suggest that peripheral blood IFN-, salivary IgA TLR2, and TLR4 are important immunological factors influencing the development of MPS lesions.

引用

页码：321 / 329

页数：9

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