Gold-Catalyzed Stereocontrolled Oxacyclization/[4+2]-Cycloaddition Cascade of Ketone-Allene Substrates

被引：79

作者：

Teng, Tse-Min ^{[1
]}

Liu, Rai-Shung ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu, Taiwan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 27期

关键词：

EFFICIENT SYNTHESIS; PROPARGYLIC ESTERS; CYCLOADDITION; CYCLIZATION; GENERATION; ACCESS; ANNULATION; ALKENES; TANDEM; ETHERS;

D O I：

10.1021/ja1043837

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the first success on the Au-catalyzed tandem oxacyclization/[4+2]-cycloaddition cascade using ketone-allene substrates to give highly substituted oxacyclics with excellent stereocontrol. In contrast to oxo-alkyne substrates, the resulting cycloadducts are isolable and efficiently produced from a reasonable scope of enol ethers.

引用

页码：9298 / 9300

页数：3

共 31 条

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