De-Escalation Strategies for Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma-Where Are We Now?

被引：15
作者：
Silver, Jennifer A. [1 ,2 ]
Turkdogan, Sena [1 ,2 ]
Roy, Catherine F. [1 ,2 ]
Subramaniam, Thavakumar [1 ,2 ]
Henry, Melissa [2 ,3 ,4 ,5 ]
Sadeghi, Nader [1 ,2 ,6 ]
机构：
[1] McGill Univ Hlth Ctr, Dept Otolaryngol Head & Neck Surg, Montreal, PQ H4A 3JI, Canada
[2] McGill Univ, Dept Otolaryngol Head & Neck Surg, Montreal, PQ H4A 3JI, Canada
[3] McGill Univ, Gerald Bronfman Dept Oncol, Montreal, PQ H4A 3JI, Canada
[4] Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada
[5] Jewish Gen Hosp, Segal Canc Ctr, Montreal, PQ H3T 1E2, Canada
[6] McGill Univ, Res Inst, Ctr Hlth, Montreal, PQ H4A 3JI, Canada
来源：
CURRENT ONCOLOGY | 2022年 / 29卷 / 05期
关键词：
oropharyngeal squamous cell carcinoma; human papillomavirus; de-escalation; transoral surgery; TRANSORAL ROBOTIC SURGERY; LOCALLY ADVANCED HEAD; INDUCTION CHEMOTHERAPY; RANDOMIZED-TRIAL; NECK-CANCER; FUNCTIONAL OUTCOMES; RADIATION-THERAPY; SALIVARY-GLANDS; POSITIVE HEAD; RADIOTHERAPY;
D O I：
10.3390/curroncol29050295
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The prevalence of oropharyngeal squamous cell carcinoma has been increasing in North America due to human papillomavirus-associated disease. It is molecularly distinct and differs from other head and neck cancers due to the young population and high survival rate. The treatment regimens currently in place cause significant long-term toxicities. Studies have transitioned from mortality-based outcomes to patient-reported outcomes assessing quality of life. There are many completed and ongoing trials investigating alternative therapy regimens or de-escalation strategies to minimize the negative secondary effects while maintaining overall survival and disease-free survival. The goal of this review is to discuss the most recent advancements within the field while summarizing and reviewing the available evidence.
引用
收藏
页码：3668 / 3697
页数：30
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