ISIDOG Consensus Guidelines on COVID-19 Vaccination for Women before, during and after Pregnancy

被引:25
作者
Donders, Gilbert G. G. [1 ,2 ,3 ]
Grinceviciene, Svitrigaile [4 ,5 ]
Haldre, Kai [6 ]
Lonnee-Hoffmann, Risa [7 ]
Donders, Francesca [1 ]
Tsiakalos, Aristotelis [8 ]
Adriaanse, Albert [9 ]
de Oliveira, Jose Martinez [10 ]
Ault, Kevin [11 ]
Mendling, Werner [12 ]
机构
[1] Femicare VZW Clin Res Women, B-3300 Tienen, Belgium
[2] Univ Hosp Antwerp, Dept Obstet & Gynecol, B-2650 Edegem, Belgium
[3] President Int Soc Infect Dis ISIDOG, B-3300 Tienen, Belgium
[4] Vilnius Univ, Dept Biothemodynam & Drug Design, Inst Biotechnol, LT-01513 Vilnius, Lithuania
[5] Vilnius Univ, Life Sci Ctr, LT-01513 Vilnius, Lithuania
[6] East Tallin Cent Hosp Womens Clin, EE-10138 Tallinn, Estonia
[7] Hosp St Olav, Dept Gynecol, N-7030 Trondheim, Norway
[8] LETO Obstetrician Gynecol & Surg Ctr, Dept Obstet & Gynecol, Athens 11525, Greece
[9] Med Ctr Alkmaar, Dept Obstet & Gynecol, NL-1814 Alkmaar, Netherlands
[10] Univ Beira Interior, Dept Obstet & Gynecol, P-6201001 Covilha, Portugal
[11] Univ Kansas, Dept Obstet & Gynecol, Med Ctr, Kansas City, KS 66160 USA
[12] German Ctr Infect Obstet & Gynceol, Dept Obstet & Gynecol, D-42283 Wupperthal, Germany
关键词
vaccine; pregnancy complication; SARS-CoV-2; COVID-19; maternal complications; pandemic; prevention; safety; CORONAVIRUS DISEASE 2019; PERINATAL OUTCOMES; SARS-COV-2; INFECTION;
D O I
10.3390/jcm10132902
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction. Sars-CoV-2 infection poses particular problems in pregnancy, as the infection more frequently causes severe complications than in unaffected pregnant women or nonpregnant women with SARS-CoV-2 infection. Now that vaccination is available and rapidly being implemented worldwide, the question arises whether pregnant women should be vaccinated, and if so, whether they should receive priority. Methods. Available scientific data and available guidelines about vaccination against SARS-CoV-2 were collected by the Guideline Committee of the International Society of Infectious Diseases in Obstetrics and Gynecology (ISIDOG) and were analyzed, discussed and summarized as guidelines for healthcare workers caring for pregnant women. Concluding statements were graded according to the Oxford evidence-based medicine grading system. Results. There is evidence to consider pregnancy as a risk factor for serious complications of COVID-19 infection, even in the absence of additional risk factors, such as hypertension, diabetes and obesity which increase these risks even more in pregnancy. Currently available data slightly favor mRNA-based vaccines above vector-based vaccines during pregnancy and breastfeeding, until more safety data become available. Conclusion. ISIDOG advises policy makers and societies to prioritize pregnant women to receive vaccination against SARS-CoV-2 and favor the mRNA vaccines until further safety information becomes available.
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页数:11
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